Accuracy of the heart rate detection:
Comparing our algorithm using the first derivative of the photoplethysmography to EKG, the coefficient of correlation r=0.99.
Accuracy of the HRV analysis:
According to the standard ANSI/AAMI EC57, our results are in compliance with the Input MIT-BIH database.
Research and development i.e. clinical studies:
The PTG spectral analysis using OXI_W is patented. Results are Off label Use.
Gold standard of Insulin resistance assessment:
Hyperinsulinemic Euglycemic Clamp (HEC), PTG-TP marker returns a sensitivity = 95.7%, specificity = 84,4% and the area under the ROC curve (AUC) = 0.929 for identifying insulin resistance.
Oral Glucose Tolerance Test (OGTT):
The correlations between the OGTT and photoplethysmography index (PTGi) were: r = – 0.56 (p = 0.003) for glucose and r = – 0.41 (p = 0.04)for insulin
PTGi returns a sensitivity of 86.1% and specificity of 87.1% and the area under the ROC curve ( AUC) = 0.926 for identifying endothelial function.